Radioactive polonium is lethal in microscopic microscopic doses
If you want a toxin that does maximum damage with minimal effort, polonium-210 is the reigning champion. Just a few micrograms ingested or inhaled will relentlessly bombard your internal structures with alpha particles, shredding your DNA like a microscopic paper shredder. It is arguably one of the most toxic substances known, completely dismantling cellular integrity while being virtually undetectable.

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