A treatment aimed at “reducing” illness

When George Washington became dangerously ill with a throat infection in December 1799, his doctors faced a frightening problem: he was struggling to breathe. Eighteenth-century medicine often treated severe illness by bloodletting—deliberately removing blood to reduce what physicians believed was an excess of blood or inflammation in the body.

That reasoning made the intervention seem purposeful, not reckless. If illness represented an imbalance, taking blood away was supposed to restore balance and ease the body’s distress. But the treatment could also leave a patient weaker, especially during an illness already taxing breathing and circulation.

How the remedy could deepen the crisis

Washington’s doctors removed about 80 ounces of blood in less than 12 hours—roughly 2.4 liters. Losing that much blood can sharply reduce the fluid circulating through the body and the amount of oxygen-carrying red blood cells available. The heart then has to work harder to deliver oxygen, while the patient has less reserve to withstand the original illness.

The throat infection itself was severe, and the surviving account does not let us assign a precise share of the outcome to any one treatment. Still, such extensive blood loss likely added a major physical burden at the moment Washington needed strength to keep breathing and maintain circulation.

The consequence of a familiar medical theory

Bloodletting was not an isolated mistake by one doctor; it reflected a medical system in which removing blood was a standard response to many conditions. Washington’s final hours show the danger of a treatment that appeared logical within that system but could compound the very crisis it was meant to relieve. The striking detail is not simply that doctors took blood, but how much—and how quickly—while their patient was already gravely ill.