A closer look

Why settle for generic nanoparticles when you can aggressively fold the building blocks of life into functional microscopic origami? Bioengineers have weaponized the predictable pairing of DNA bases to force synthetic strands to self-assemble into complex 2D and 3D shapes. These nanoscale constructs range from purely flex-worthy microscopic smiley faces to highly targeted cellular lockboxes that physically hinge open to dump toxic chemotherapy drugs directly into cancer cells.