How doctors numbed skin with instant frostbite
If you couldn't access cocaine—which was wildly popular for numbing eyeballs in the 1800s—doctors had a much more brutal alternative. They would spray a highly volatile chemical like ether directly onto the patient's skin until the rapid evaporation literally froze the flesh solid. Numbness was achieved purely by giving the patient instantaneous, localized frostbite. So advanced.

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